To quote - "The GLP-1 group had a 9 times greater risk of pancreatitis, a 4 times greater risk of bowel obstruction, and a more than 3 times greater risk of gastroparesis". Oh and don't have surgery while you're taking it - "Reports of people using GLP-1 agonists who regurgitated or aspirated food during anesthesia surfaced this spring in scientific journals. Some of the reports were striking due to the volume of stomach contents the patients regurgitated despite having fasted." Oh, and self harm "This July, case reports of depression and suicidality prompted the European Medicines Agency to review about 150 instances of possible self-injury and suicidal thoughts among people using liraglutide or semaglutide". Muscle wastage might be the least of our issues on these drugs!
I actually intended to cite this article in talking about Wegovy, but I forgot. Thanks for reminding me. Many side effects, and that's not to mention the loss of lean body mass.
Dear Mike, belated Happy Birthday to MD ! And belated anniversary to you and MD !
I love the Herm of Dionysos. When you make a herm to delineate your boundary in your next property you’ll have to post a photo of it for readers. Btw, have you still not bought a house ?
I got a bit confused about GIP - I thought it was good for bone health (previous Arrows) ? Do you mean it’s good in ‘normal’ amounts but not when it keeps getting increased by the combination of fat and carbs because of the rise in insulin ? I want my bone density to increase !
You'll get plenty of GIP by eating fat and protein. I think there is a threshold effect. Once that threshold is reached, your bone is maximally stimulated. And you can reach that threshold with fat and protein, both of which raise GIP, but not to the point that it skyrockets your insulin.
For the Greek boundary marker I think you meant two plus millennia ago, not two plus centuries. I thought the inclusion of the phallus interesting. Made me think of dogs pissing to mark their boundaries. It seems a bit flaccid to be a symbol of fertility.
You are correct re millennia. How did I miss that? Agreed re the flaccidity, but who knows what their thought processes were back two millennia ago. Thanks for the correction.
Great read, as usual Doc! Also, nice to read an article that didn’t mention Covid once! Not to drag that crap back out of the closet, (but I’m going to) was wondering what your thoughts are on the whole “shedding” thing that’s been popping up of late. Are we “anti-vaxxers” at risk of paying for other people’s bad decisions?
Good grief I snorted more coffee this morning than usual - first over the boundary marker, (the Getty Villa Museum rabbit hole was a beautiful place to visit) then over "riddle me this." Just a thoroughly enjoyable read - as usual. You're the one who introduced me to Briggs through his Hillsdale College talk - been reading him ever since. And, quite frankly, reading your stuff has awoken me to the identity politics issue - you know, "I don't have to read that because it's "those guys". So now I read it or listen to it. Amazing how often "they" are right - or have a valid point (or fifty). And was it in Malcolm Kendrick's latest column that I read doctors get paid "per tick" - i.e. for ticking off boxes that show they've prescribed a stating (or any number of other drugs)? No wonder it's hard to get out of the doc's office without a handful of drugs. Why didn't Nancy Regan's "just say no" apply to those drugs??
Have a great family Thanksgiving!
Just a few . . .
till I get it figure out.
either "till I figure it out" or "till I get it figured out"
412.9 billion dollars. That’s billions with a B. $419.9B!
412 or 419?
he sequestration of fat in the fat cells
The sequestration . . .
when the hop from their government jobs into industry
As always, thanks for alerting me to the typos. All fixed, plus a few others. I can't believe how obvious these things are once you see them, and how easy they are to overlook. If you're ever in Malibu, CA with time to kill, visit the Getty Villa. You have to buy a ticket to park, which includes admission. You can't just walk up. It's never crowded (or we've just been phenomenally lucky), and you can wander at leisure. It's a gorgeous place.
Yes, the pay per tick thing is disgusting. I've spent more of my professional life taking people off of meds than I have putting them on.
Conclusions "More than 70% of medicines that entered the French market during the 10-year period originated in the commercial sector. Although most medicines were not graded as providing clinical benefit, medicines originating in the academic setting were more likely to be graded as conferring clinical benefit than those originating in the commercial setting."
In other words, most new medicines are rubbish, and those produced by Pharma are even more rubbish than those not-produced by Pharma. Who knew?!
I have to wonder if CAD was the result of partially hydrogenated fats that produced trans-fats as an unintended consequence. The trans fats inflame the arteries. The body produces cholesterol to patch the inflamed lesions. Chunks of cholesterol can come loose, causing a stroke or myocardial infarction. Doctors blame cholesterol, demonize prawns and lobster and eggs (lots of cholesterol) and put everyone on statins. Other doctors say, no-- it's saturated fats that turn into cholesterol, so everything including donuts becomes fat-free. Nothing is fixed-- people still get CAD and now, diabetes. Arghhh!
"Chunks of cholesterol" don't really come loose with an MI. The plaque ruptures, and the platelets in the blood along with other clotting factors try to basically put a scab (a blood clot) on the wound. If this scab breaks free and floats downstream to the point it occluded an artery, you have a myocardial infarction, i.e, heart attack.
2. "I tried a whole grain once. I was an adolescent and was riding in the back of my grandfather’s pickup as he drove around his farm gathering eggs from the hen houses, slopping the hogs, and doing all the other chores. In the back of his pickup was some freshly harvested wheat. I knew bread was made from wheat, so I decided to peel off some of the grains of wheat and eat them. I figured it would have a bread-y kind of taste."
This reminds me of a story that has nothing to do with diet but is somewhat health-related. In the mid 1960's, when my brother and I were both pre-teens, our family was visiting my grandmother's farm in southwest Virginia. We had an uncle on granny's side of the family who raised tobacco and he'd built a drying barn on granny's place to cure his tobacco in.
We had the run of the farm while our folks visited, and at one point we wandered into that drying barn and found it full of tobacco hung to dry: whole plants hanging upside down. They were brown with a sort of leathery texture to their leaves. Since we'd seen many of the locals in Virginia chewing tobacco, we decided to try chewing some of that raw, partially-dried weed ourselves. We were too young to know the difference between uncured weed and processed "Red Man chew."
So we both tore a handful out of a leaf and started in... and then stopped pretty quickly because it nauseated us both. One, maybe both, of us lost our lunch that day. Luckily, I don't think either of us swallowed any; I imagine that'd have been even more painful.
3. Kudos for linking Reason's "Unintended Consequences" video. That series is one of my favorites in their video productions.
Re Semaglutide, this article hit my inbox earlier in the week "As Semaglutide’s Popularity Soars, Rare but Serious Adverse Effects Are Emerging" - https://jamanetwork.com/journals/jama/fullarticle/2812192
To quote - "The GLP-1 group had a 9 times greater risk of pancreatitis, a 4 times greater risk of bowel obstruction, and a more than 3 times greater risk of gastroparesis". Oh and don't have surgery while you're taking it - "Reports of people using GLP-1 agonists who regurgitated or aspirated food during anesthesia surfaced this spring in scientific journals. Some of the reports were striking due to the volume of stomach contents the patients regurgitated despite having fasted." Oh, and self harm "This July, case reports of depression and suicidality prompted the European Medicines Agency to review about 150 instances of possible self-injury and suicidal thoughts among people using liraglutide or semaglutide". Muscle wastage might be the least of our issues on these drugs!
I actually intended to cite this article in talking about Wegovy, but I forgot. Thanks for reminding me. Many side effects, and that's not to mention the loss of lean body mass.
Dear Mike, belated Happy Birthday to MD ! And belated anniversary to you and MD !
I love the Herm of Dionysos. When you make a herm to delineate your boundary in your next property you’ll have to post a photo of it for readers. Btw, have you still not bought a house ?
I got a bit confused about GIP - I thought it was good for bone health (previous Arrows) ? Do you mean it’s good in ‘normal’ amounts but not when it keeps getting increased by the combination of fat and carbs because of the rise in insulin ? I want my bone density to increase !
You'll get plenty of GIP by eating fat and protein. I think there is a threshold effect. Once that threshold is reached, your bone is maximally stimulated. And you can reach that threshold with fat and protein, both of which raise GIP, but not to the point that it skyrockets your insulin.
For the Greek boundary marker I think you meant two plus millennia ago, not two plus centuries. I thought the inclusion of the phallus interesting. Made me think of dogs pissing to mark their boundaries. It seems a bit flaccid to be a symbol of fertility.
You are correct re millennia. How did I miss that? Agreed re the flaccidity, but who knows what their thought processes were back two millennia ago. Thanks for the correction.
It's flaccid to prevent vandals from, um, using it lol. Pervs are not new to the world.
Great read, as usual Doc! Also, nice to read an article that didn’t mention Covid once! Not to drag that crap back out of the closet, (but I’m going to) was wondering what your thoughts are on the whole “shedding” thing that’s been popping up of late. Are we “anti-vaxxers” at risk of paying for other people’s bad decisions?
I think the shedding thing is nonsense, but that's just off the top of my head. I haven't really read much about it.
Good grief I snorted more coffee this morning than usual - first over the boundary marker, (the Getty Villa Museum rabbit hole was a beautiful place to visit) then over "riddle me this." Just a thoroughly enjoyable read - as usual. You're the one who introduced me to Briggs through his Hillsdale College talk - been reading him ever since. And, quite frankly, reading your stuff has awoken me to the identity politics issue - you know, "I don't have to read that because it's "those guys". So now I read it or listen to it. Amazing how often "they" are right - or have a valid point (or fifty). And was it in Malcolm Kendrick's latest column that I read doctors get paid "per tick" - i.e. for ticking off boxes that show they've prescribed a stating (or any number of other drugs)? No wonder it's hard to get out of the doc's office without a handful of drugs. Why didn't Nancy Regan's "just say no" apply to those drugs??
Have a great family Thanksgiving!
Just a few . . .
till I get it figure out.
either "till I figure it out" or "till I get it figured out"
412.9 billion dollars. That’s billions with a B. $419.9B!
412 or 419?
he sequestration of fat in the fat cells
The sequestration . . .
when the hop from their government jobs into industry
when they hop from
\If we don’t pay,
delete the \
As always, thanks for alerting me to the typos. All fixed, plus a few others. I can't believe how obvious these things are once you see them, and how easy they are to overlook. If you're ever in Malibu, CA with time to kill, visit the Getty Villa. You have to buy a ticket to park, which includes admission. You can't just walk up. It's never crowded (or we've just been phenomenally lucky), and you can wander at leisure. It's a gorgeous place.
Yes, the pay per tick thing is disgusting. I've spent more of my professional life taking people off of meds than I have putting them on.
That should be "prescribed a statin" - grrrrr
I tried to fix it for you, but Substack won't let me edit comments. I can edit mine, but apparently not anyone else's.
This is slightly off-topic, but may be of interest to readers.
Provenance and Clinical Benefit of Medicines Introduced to the French Market, 2008 to 2018
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2811777
Conclusions "More than 70% of medicines that entered the French market during the 10-year period originated in the commercial sector. Although most medicines were not graded as providing clinical benefit, medicines originating in the academic setting were more likely to be graded as conferring clinical benefit than those originating in the commercial setting."
In other words, most new medicines are rubbish, and those produced by Pharma are even more rubbish than those not-produced by Pharma. Who knew?!
Figures. Thanks for the link.
I have to wonder if CAD was the result of partially hydrogenated fats that produced trans-fats as an unintended consequence. The trans fats inflame the arteries. The body produces cholesterol to patch the inflamed lesions. Chunks of cholesterol can come loose, causing a stroke or myocardial infarction. Doctors blame cholesterol, demonize prawns and lobster and eggs (lots of cholesterol) and put everyone on statins. Other doctors say, no-- it's saturated fats that turn into cholesterol, so everything including donuts becomes fat-free. Nothing is fixed-- people still get CAD and now, diabetes. Arghhh!
"Chunks of cholesterol" don't really come loose with an MI. The plaque ruptures, and the platelets in the blood along with other clotting factors try to basically put a scab (a blood clot) on the wound. If this scab breaks free and floats downstream to the point it occluded an artery, you have a myocardial infarction, i.e, heart attack.
1. Your "Herm of Dionysos" image reminds of the Manneken Pis fountain in Brussels. See https://theculturetrip.com/europe/belgium/articles/the-legendary-stories-of-manneken-pis
2. "I tried a whole grain once. I was an adolescent and was riding in the back of my grandfather’s pickup as he drove around his farm gathering eggs from the hen houses, slopping the hogs, and doing all the other chores. In the back of his pickup was some freshly harvested wheat. I knew bread was made from wheat, so I decided to peel off some of the grains of wheat and eat them. I figured it would have a bread-y kind of taste."
This reminds me of a story that has nothing to do with diet but is somewhat health-related. In the mid 1960's, when my brother and I were both pre-teens, our family was visiting my grandmother's farm in southwest Virginia. We had an uncle on granny's side of the family who raised tobacco and he'd built a drying barn on granny's place to cure his tobacco in.
We had the run of the farm while our folks visited, and at one point we wandered into that drying barn and found it full of tobacco hung to dry: whole plants hanging upside down. They were brown with a sort of leathery texture to their leaves. Since we'd seen many of the locals in Virginia chewing tobacco, we decided to try chewing some of that raw, partially-dried weed ourselves. We were too young to know the difference between uncured weed and processed "Red Man chew."
So we both tore a handful out of a leaf and started in... and then stopped pretty quickly because it nauseated us both. One, maybe both, of us lost our lunch that day. Luckily, I don't think either of us swallowed any; I imagine that'd have been even more painful.
3. Kudos for linking Reason's "Unintended Consequences" video. That series is one of my favorites in their video productions.